Focus on Oral Antiplatelet Therapy
for Medical Management of ACS
MedicineWRAP CME Disclosure
Please read this notice and click the acknowledgement
at the bottom of the page to continue.
Method of Physician Participation
Utilized in Learning Process:
There are no fees for participating and receiving CME credit for this activity. During the period December 12, 2011 through December 12, 2013 participants must 1) read the learning objectives and faculty disclosures; 2) study the educational activity; 3) register and complete the evaluation form; and 4) print out your CME certificate.
Time to Complete Educational Activity:
In this web-based program, physicians will learn how recent advances in basic and clinical research have helped to advance the understanding of treatment advances in antiplatelet therapy for the management of acute coronary syndrome.
December 12, 2011
December 12, 2013
This program is intended for all cardiovascular-focused clinicians, investigators, program directors, and healthcare providers caring for patients with cardiovascular disease, ACS, and related conditions
Enrollment for this WebCAST is complimentary, and clinicians are invited to participate in this CME-certified WebCAST and/or share this invitation with other colleagues, departmental staff members, and healthcare professionals.
This activity is supported by an educational grant
from Bristol-Myers Squibb
Physician Continuing Education
This activity has been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education through the joint sponsorship of The University of Massachusetts Medical School, Office of CME and CMEducation Resources, LLC. The University of Massachusetts Medical School is accredited by the ACCME to provide continuing medical education for physicians.
The University of Massachusetts Medical School designates this enduring material for a maximum of 2.0 AMA PRA Category 1 Credit(s)™. Physicians should only claim credit commensurate with the extent of their participation in the activity.
Disclosure of Conflicts of Interest:
It is the policy of the University of Massachusetts Medical School to ensure fair balance, independence, objectivity, and scientific rigor in all activities. All faculty participating in CME activities sponsored by the University of Massachusetts Medical School are required to present evidence-based data, identify and reference off-label product use and disclose all relevant financial relationships with those supporting the activity or others whose products or services are discussed. Faculty disclosure will be provided in the activity materials
Program Faculty and Disclosures:
Charles V. Pollack, Jr., M.A., M.D., FACEP
Professor and Chairman, Emergency Medicine
University of Pennsylvania Health System
Dr. Charles Pollack discloses that he has been a consultant to Bristol-Myers Squibb, The Medicines Company, sanofi-aventis, Genentech and Schering-Plough. He has received direct research support from GlaxoSmithKline, and has been a speaker for Schering-Plough, Bristol-Myers Squibb, and sanofi-aventis.
Advisory Board/Consultant: Amgen, Merck, Roche, Sanofi-aventis
Stockholder: Omthera Pharmaceuticals
Program Managers and Web Editor Disclosure:
Program Manager Gideon Bosker, MD has nothing to disclose.
Program Reviewer Denise Leary has nothing to disclose.
Physicians, pharmacists, and other healthcare providers will:
- Be better educated about and more clinically proficient at implementing
current ACC/AHA/ACEP/SCAI guidelines for management of UA/NSTEMI as
these recommendations relate to use of antiplatelet and other antithrombotic
agents in patients undergoing both acute and long-term medical
management of UA/NSTE-ACS.
- Become more aware of the role that each clinical specialty group and
stakeholder—emergency physician, hospitalist, primary care/internal
medicine, cardiologist—has for ensuring guideline-adherent implementation
of antiplatelet therapy at each phase of the medical management cycle for
ACS, including ED, hospital, CCU, pre- and post-angiography, hospital
discharge, and post-hospital, enduring medical management of ACS.
- Become more aware of the importance that multiple specialty groups
involved in the ACS management cycle adhere to published, evidence-based
guidelines as the core strategy for medical management of patients with
- Be better educated about and more clinically proficient at optimizing
medical treatment of NSTE-ACS, based on proper risk stratification strategies
which will help identify patients who are best treated with a conservative
(medical) approach for UA/NSTEMI, in both the acute and long-term settings.
- Become more clinically skilled at identifying ACS patients who are
amenable to a medical strategy for their treatment, and be better able to
apply the results of landmark studies outlining how to implement a
selectively invasive strategy for ACS, and what the impact is of medical-based
strategies for ACS is one patient outcomes.
- Be better educated and better able to implement dosing and evidence-based
guidelines for long-term antiplatelet management of ACS (UA and
NSTEMI) patients who, based on risk stratification criteria or findings at
angiography, are appropriate for a long-term medical strategy employing
antiplatelet agents and other cardioprotective therapies.
- Be better educated, based on scientific evidence and clinical trial data, on
how best to assess the need or suitability of medically managed ACS patients
for specific genetic testing prior to antiplatelet therapy; and how to
implement current, evidence-based standards of clinical practice endorsed by
published guidelines, FDA, and Clinical Alerts issued by the ACCF/AHA.
- Be better educated and understand the implications and risks associated
with suboptimal treatment of medical managed ACS, and the comparative
outcomes of patients managed with appropriate doses and duration
guideline-mandated oral antithrombotic/antiplatelet therapy versus those
receiving suboptimal medical therapy for ACS.
- Be better educated about the foundation role of oral antiplatelet agents
when managing acutely ill patients presenting to the ED or CCU with NSTEACS
or STEMI, and more aware of guidelines and recommendations for
continuing oral therapy in the post-hospitalization period.
- Be better able to implement optimal dosing, duration of therapy, and
timing strategies for antiplatelet agents, i.e. putting into practice, at all
phases of ACS care, those approaches that produce the best balance of
thrombosis mitigating outcomes and bleeding safety, for oral antiplatelet
agents in the setting of medical therapy for ACS
- Become more clinically skilled at initial risk stratification of patients
presenting with UA or NSTE-ACS, as a basis for determining optimal,
guideline-compliant approaches to antiplatelet therapy for initial and long-term
- Become more educated about the pathophysiology, mechanisms of action,
resistance, pharmacokinetics, and pharmacodynamics of antiplatelet agents
and how these factors should impact clinical therapeutics for medical
managed patients with ACS, including PPI-antiplatelet therapy interactions.
- Become more skilled at interpreting and analyzing landmark trials and
CRUSADE registry data in order to facilitate optimal drug selection, with a
focus on implementing the optimal approach to timing, selection, dosing,
combination therapy, and appropriate use of antiplatelet agents in the setting
of NSTE-ACS and UA.
- Become more aware of the implications of the CRUSADE, DUKE, GRACE,
and REACH registries and how they have helped identify and illuminate
clinical practice gaps in medical management of patients with ACS.
- Better educated and skilled at applying AHA/ACC guidelines for
management of NSTE-ACS and the Year 2008 STEMI Update, with a focus on
timing of administration and special considerations for long-term antiplatelet
therapy depending on risk stratification, invasive vs. non-invasive strategies,
- Better educated about the pharmacology, dose, and side effects of
antiplatelet agents employed for medical management of ACS.
- Become more proficient at prescribing strategies for antiplatelet agents that
reduce side effects and increase the likelihood of optimal clinical outcomes in
patients with ACS, including indications for using PPIs in combination with
- Be better able to characterize and distinguish among safety profiles and
bleeding risks and efficacy characteristics of oral antiplatelet agents used to
medically manage ACS patients in the acute and long-term, post-ACS, post-hospitalization setting.
Hardware and Software Requirements:
To participate in this program, viewers must have a PC or Macintosh computer that has active, ongoing internet access for the duration of the program, as well as a compatible Flash-viewer. An email address is required for registration, and a printer is required to printout the CME certificate.
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